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Impact of NADH on gene expression of Streptococcus pneumoniae and role of Rex as a transcriptional repressor of the Rex regulon

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Streptococcus pneumoniae D39

PROVIDER: GSE94573 | GEO | 2018/06/01

REPOSITORIES: GEO

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NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon.

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Impact of NADH on gene expression of Streptococcus pneumoniae and role of Rex as a transcriptional repressor of the Rex regulon

Project description:Impact of NADH on gene expression of Streptococcus pneumoniae and role of Rex as a transcriptional repressor of the Rex regulon

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Impact of rex delation on the transcriptome of Streptococcus pneumoniae D39

Project description:The objective of this comparison was to identify the impact of rex deletion on the transcriptome of Streptococcus pneumoniae D39. This comparison showed that the transcriptional regulator, Rex acts as a transcriptional repressor of a number of genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in niacin uptake and biosynthesis in the presence of NADH. In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39 to NADH. Transcriptome comparison of the D39 wild-type grown in chemically-defined medium (CDM) with 0 mg/ml NADH to 0.5 mg/ml NADH revealed elevated expression of various genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in the transport and biosynthesis of niacin. Microarray results were further confirmed by β-galactosidase assays. Promoter-lacZ fusions assays and microarray studies showed that the transcriptional regulator, Rex acts as a transcriptional repressor of a number of genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in niacin uptake and biosynthesis in the presence of NADH. The putative operator site of Rex in the promoter regions of Rex-regulated genes is predicted and confirmed by promoter mutational experiments.

2018-06-01 | GSE94571 | GEO

Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae.

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Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae.

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Maltose-dependent transcriptional regulation of the mal regulon by MalR in Streptococcus pneumoniae

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-04-23 | E-GEOD-65550 | biostudies-arrayexpress

A Rex family transcriptional repressor influences H2O2 accumulation by Enterococcus faecalis.

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Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima.

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Maltose-dependent transcriptional regulation of the mal regulon by MalR in Streptococcus pneumoniae

Project description:The maltose regulon (mal regulon) has previously been shown to consist of the mal gene cluster (malQP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study, we have further elucidated the complete mal regulon in S. pneumoniae D39 using microarray analyses and β-galactosidase assays. In addition to the mal gene cluster, the complete mal regulon of S. pneumoniae D39 consists of a pullulanase (PulA), a glucosidase (DexB), a glucokinase (RokB), a PTS component (PtsG) and an amylase (AmyA2). Our microarray studies and β-galactosidase assays further showed that the LacI-family transcriptional regulator MalR represses the expression of the mal regulon in the absence of maltose. Furthermore, the role of the pleiotropic transcriptional regulator CcpA in the regulation of the mal regulon in the presence of maltose was also explored. Our microarray analysis with a ΔccpA strain showed that CcpA only represses the expression of the malXCD operon and the pulA gene in the presence of maltose. This SuperSeries is composed of the SubSeries listed below.

2015-04-23 | GSE65550 | GEO

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