Elucidation of roles of Nr4a nuclear orphan receptors and Foxp3 in thymic Treg cell development

ABSTRACT: Both Nr4a family nuclear orphan receptors and Foxp3 had been revealed to be crucial transcription factors in Treg cell development. In this study, to reveal their roles in a Treg cell developmental transcriptional programs, we compared transcriptomes among wild-type conventional CD4 T (Tconv) cells, wild-type Treg cells, Nr4a-triple-knockout (Nr4a-TKO) Treg precursor (preTreg) cells, and Foxp3-KO preTreg cells by microarray.

ORGANISM(S): Mus musculus

PROVIDER: GSE94727 | GEO | 2017/02/10

SECONDARY ACCESSION(S): PRJNA373860

REPOSITORIES: GEO