Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)
SUBMITTER: Richard A Young
PROVIDER: GSE94823 | GEO | 2018-05-22
REPOSITORIES: GEO
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GSE94823_RAW.tar | Raw | |||
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Durbin Adam D AD Zimmerman Mark W MW Dharia Neekesh V NV Abraham Brian J BJ Iniguez Amanda Balboni AB Weichert-Leahey Nina N He Shuning S Krill-Burger John M JM Root David E DE Vazquez Francisca F Tsherniak Aviad A Hahn William C WC Golub Todd R TR Young Richard A RA Look A Thomas AT Stegmaier Kimberly K
Nature genetics 20180820 9
Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat effectively<sup>1</sup>. This has focused attention on tumor-specific gene dependencies that underlie tumorigenesis and thus provide valuable targets for the development of novel therapeutics. Using unbiased genome-scale CRISPR-Cas9 approaches to detect genes involved in tumor cell growth and survival<sup>2-6</sup>, we identified 147 candidate gene dependencies selective for MYCN-amplified neuroblastoma cell l ...[more]