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MRNA Expression Data from Murine Hearts of Pcyt2+/- Male and Female Mice at 8 Months of Age

ABSTRACT: Hearts were collected from Pcyt2+/- male and female mice at 8 months of age The microarray approach allows the investigation of gene expression changes of all genes in Pcyt2+/- male and female hearts.

ORGANISM(S): Mus musculus

PROVIDER: GSE95010 | GEO | 2017/02/17

SECONDARY ACCESSION(S): PRJNA375126

REPOSITORIES: GEO

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mRNA Expression Data from Murine Hearts of Pcyt2+/- Male and Female Mice at 8 Months of Age

Project description:Hearts were collected from Pcyt2+/- male and female mice at 8 months of age The microarray approach allows the investigation of gene expression changes of all genes in Pcyt2+/- male and female hearts.

2022-02-08 | GSE166342 | GEO

mRNA Expression Data from Murine Hearts of Pcyt2+/- Male and Female Mice at 8 Months of Age

Project description:mRNA Expression Data from Murine Hearts of Pcyt2+/- Male and Female Mice at 8 Months of Age

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Methamphetamine Induces Sex-Dependent Changes in Gene Expression in Male and Female Hearts

Project description:Male and female rats received daily injections of saline or methamphetamine for 10 days. Changes in gene expression were assessed by RNA sequencing either 24 hours or 30 days following the last injection. Methamphetamine induced changes in the myocardial transcriptome were significantly greater in female hearts than male hearts both in terms of the number of genes affected and the magnitude of the changes. The largest changes in female hearts involved genes that regulate the circadian clock (Dbp, Per3, Per2, BMal1, and Npas2) which is known to impact myocardial sensitivity to ischemia. These genes were unaffected by methamphetamine in male hearts. All changes in gene expression identified at day 11 returned to baseline by day 30. These data demonstrate that female rats are more sensitive than males to methamphetamine-induced changes in the myocardial transcriptome and that methamphetamine does not induce changes in myocardial transcription that persist long term after exposure to the drug has been discontinued.

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Cardiac Sex Differences in the Transcriptome of C57 Male and Female Adult Hearts

Project description:Purpose: The goals of this study are to compare adult male and female C57 mouse hearts transcriptome profiling (RNA-seq) to conclude cardiac sex differences at the mRNA level. Methods: mRNA profiles of adult male and female C57 mouse hearts were generated by deep sequencing, n=4 for each sex, using Illumina HiSeq2500. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. Results: Using an optimized data analysis workflow, we mapped about 50 million sequence reads per sample to the mouse genome (build mm10) and identified 16,160 transcripts in the mouse hearts.

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Project description:Purpose: The goals of this study are to compare E9.5 male and female C57 mouse embryonic hearts transcriptome profiling (RNA-seq) to conclude cardiac sex differences at the mRNA level. Methods: mRNA profiles of E9.5 male and female C57 mouse embryonic hearts were generated by deep sequencing, n=4 for each sex, using Illumina HiSeq2500. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. Results: Using an optimized data analysis workflow, we mapped about 30 million sequence reads per sample to the mouse genome (build mm10) and identified 16,460 transcripts in the mouse hearts.

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Male and female embryonic chicken hearts (arnol-affy-chick-445639)

Project description:The study is relevant to an understanding of the forces that lead to sex differences in the brain and other somatic tissues. Many neural and psychiatric diseases affect men and women differently, so the understanding of sex differences in brain function impacts on our understanding of why the male and female brain differ in their susceptibility to disease. Using Affymetrix chicken arrays, we will measure the gene expression in male and female embryonic chicken heart, and compare to previous studies of brain and liver. Gene expression differs in the male and female embryonic chicken heart, liver, and brain. Higher expression of Z-chromosome genes in males is found in heart, liver and brain. Comparison of heart and brain will reveal brain-specific patterns of sex differences, and patterns that apply to multiple tissues. 20 male and 20 female chicken embryos will serve as source of heart tissue. In late stage embryos, we will remove the tissue and extract total RNA. Four birds will comprise each individual sample. Thus, we will have 5 biologically independent male samples, and an equal number of female samples. Keywords: dose response

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Cardiac Sex Differences in the Transcriptome of C57 Male and Female E9.5 Hearts

Project description:Cardiac Sex Differences in the Transcriptome of C57 Male and Female E9.5 Hearts

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Cardiac Sex Differences in the Transcriptome of C57 Male and Female Adult Hearts

Project description:Cardiac Sex Differences in the Transcriptome of C57 Male and Female Adult Hearts

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Methamphetamine Induces Sex-Dependent Changes in Gene Expression in Male and Female Hearts

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