Genomics

Dataset Information

36

BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice


ABSTRACT: We analyzed the transcriptomic changes and Brd4 global occupancy in Th17 cells treated with JQ1 and MS402. We find that MS402 selectively targets Th17 cells and displaces Brd4 occupancy at Th17-selective genes. Overall design: RNA-seq samples were analyzed from Th17 cells treated with JQ1 and MS402. ChIP-seq samples were analyzed to determine global Brd4 occupancy in response to MS402 treatement.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Rajal Sharma  

PROVIDER: GSE95052 | GEO | 2017-04-01

SECONDARY ACCESSION(S): PRJNA375822

REPOSITORIES: GEO

Dataset's files

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GSE95052_RAW.tar Raw
GSE95052_Th17_treated_counts.txt.gz Txt
filelist.txt Txt
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