BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

ABSTRACT: We analyzed the transcriptomic changes and Brd4 global occupancy in Th17 cells treated with JQ1 and MS402. We find that MS402 selectively targets Th17 cells and displaces Brd4 occupancy at Th17-selective genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE95052 | GEO | 2017/04/01

SECONDARY ACCESSION(S): PRJNA375822

REPOSITORIES: GEO