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Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [UMI-4C]

ABSTRACT: Genome-wide chromosome conformation capture (Hi-C) and promoter-capture Hi-C (CHi-C) were performed during epidermal differentiation. These data indicate that dynamic and constitutive enhancer-promoter contacts combine to control gene induction during differentiation and that chromosome conformation enables discovery of new TFs with distinct roles in this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95098 | GEO | 2017/06/28

SECONDARY ACCESSION(S): PRJNA376091

REPOSITORIES: GEO

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Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [HiC_CHiC]

Project description:Genome-wide chromosome conformation capture (Hi-C) and promoter-capture Hi-C (CHi-C) were performed during epidermal differentiation. These data indicate that dynamic and constitutive enhancer-promoter contacts combine to control gene induction during differentiation and that chromosome conformation enables discovery of new TFs with distinct roles in this process.

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