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Fas- and DR3-dependent transcriptome changes in naïve T-cells from EBV carrier during and after acute mononucleosis

ABSTRACT: EBV-encoded proteins interfere with extrinsic and intrinsic apoptotic pathways so that homeostasis of infected cells shifts to survival and proliferation favoring to evasion of virus from immune surveillance.The aim of investigation is to reveal the key factors regulating Fas- и DR3-triggered cascades influenced by EBV in naïve T-cells. We developed the splicing-sensitive microarray covering 221 genes encoding apoptosis-associated factors, adaptor proteins, kinases, RNA-binding proteins (including spliceosome elements) etc. Naïve CD4+ and CD8+ T-cells isolated from the same EBV-infected patient during acute mononucleosis and after therapy were analyzed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95126 | GEO | 2017/02/22

SECONDARY ACCESSION(S): PRJNA376150

REPOSITORIES: GEO

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