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Transcriptome analysis in rat

ABSTRACT: Large scale transcriptome analysis of Wistar and Sprague Dawley rat tissues. Keywords: other

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE952 | GEO | 2004/01/27

SECONDARY ACCESSION(S): PRJNA87995

REPOSITORIES: GEO

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Transcriptome analysis in rat

Project description:Large scale transcriptome analysis of Wistar and Sprague Dawley rat tissues. Keywords: other

2004-01-27 | E-GEOD-952 | biostudies-arrayexpress

The Transcriptome of the rat hypothalamo-neurohypophyseal system is highly strain-dependant

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Progesterone responsive uterine transcriptome in rat

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Bis-(2-chloroethyl) sulfide exposure time course and dose response in the rat lung

Project description:Male Sprague-dawley rats were exposed to saline, isopropyl alcohol, 1mg/kg, 3mg/kg or 6 mg/kg sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr before analysis of lung tissue by oligonucleotide array analysis. Keywords = sulfur mustard Keywords = rat Keywords = lung Keywords = bis-(2-chloroethyl) sulfide Keywords: ordered

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rat metagenome

Project description:16s rRNA of adult Sprague Dawley IGS rat: feces

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retina injury timecourse

Project description:Sprague-Dawley rat retina post-injury and control samples Keywords = Gliosis, CNS injury

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Rat model of breast cancer to dissect mechanisms of immune escape and immunotherapy sensitivity

Project description:NMU-induced sprague dawley rat model of breast cancer treated with immunotherapy to prevent tumor progression

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mRNA Levels in the Rat Liver Display Strain-Specific, Hereditary and AHR-Dependent Components

Project description:Background The rat is a major model organism in toxicogenomics and pharmacogenomics, and the use of steady-state hepatic mRNA levels to predict and understand drug toxicity and mechanism is well-established. Surprisingly, the inter- and intra-strain variability of rat mRNA expression has not been evaluated, nor has the extent of its hereditability been established. We address these issues by studying three rat strains (Long-Evans, Hans/Wistar, and Sprague-Dawley) and two F2 lines derived from Long-Evans x Hans/Wistar crosses. Results Using three independent techniques – variance analysis, linear modelling, and unsupervised pattern recognition – we characterize large amounts of both intra- and inter-strain variability in mRNA levels. Importantly, both sources of variability are highly non-random, and are enriched for specific functional groups. Specific transcription-factor binding-sites are enriched in their promoter regions, and these genes occur in “islands” throughout the rat genome. Using the two F2 crosses we study the hereditability of hepatic mRNA levels and show that the majority of rat genes appear to exhibit directional genetics, with only a small fraction having evidence for interacting loci. Finally, a comparison of inter-strain heterogeneity between mouse and rat orthologs shows more heterogeneity in rats than mice, and find that rat and mouse heterogeneity are uncorrelated. Conclusions Our results establish that hepatic mRNA levels are relatively homogeneous within rat strains, but highly variable between them. This variability may be related to increased activity specific transcription-factors, and has clear functional consequences. Future toxicogenomic and pharmacogenomic studies may take advantage of this phenomenon by surveying panels of rat strains. Keywords: Inter-Strain Comparison

2009-11-24 | GSE10448 | GEO

Single nuclei RNAseq of rat area postrema and nucleus tractus solitarius

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Neonatal rat ventricular cardiomyocytes Cells: Control vs. hypertrophic cardiomyocytes induced by isoproterenol

Project description:the expression characteristics of lncRNAs among hypertrophic cardiomyocytes induced by isoproterenol in rat ventricular myocytes from newborn Sprague-Dawley rats.

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