Transcriptomics

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Early Induction of NRF-2 Antioxidant Pathway by RHBDF2 Mediates More Rapid Cutaneous Healing in Mice


ABSTRACT: Rhomboid family protein RHBDF2, an upstream regulator of the epidermal growth factor (EGF) receptor signaling, has been implicated in cutaneous wound healing. However, the underlying molecular mechanisms are still emerging. Using a gain-of-function mutation in the mouse Rhbdf2 gene (Rhbdf2cub/cub), which shows a regenerative phenotype, we sought to identify the underlying mechanism. Transcriptome analyses were performed to identify early-stage pathways and biological processes that function post-wound healing in Rhbdf2cub/cub and control Rhbdf2+/+ mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE95250 | GEO | 2017/06/01

SECONDARY ACCESSION(S): PRJNA376509

REPOSITORIES: GEO

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