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Be1 and Be2 B cells are transcriptionally distinct

ABSTRACT: B cells cultured in the presence of Th1 CD4 T cells (Be1) or Th2 CD4 T cells (Be2) lead to distinct phenotypic outcomes. To determine when the phenotypic differences emerged, IgD positive and IgD negative Be1 and Be2 cells were isolated from cultures derived from 3 independent donors and RNA-seq performed. These data define the transcriptional differences of Be1 and Be2 cells ad distinct differentiation stages and show that Be1 B cells contain a pre-ASC signature that is absent from Be2 B cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95282 | GEO | 2019/05/17

REPOSITORIES: GEO

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