Genomics

Dataset Information

45

Affymetrix SNP array data for acute myeloid leukemia samples


ABSTRACT: Pediatric patients with de novo acute myeloid leukemia. To define genomic architecture, we performed genome-wide copy number abberation analysis in 460 paired diagnostic-remission bone marrow aspirates. Overall design: Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved diagnostic and remission bone marrow samples. Copy number aberration analysis of Affymetrix 6.0 SNP arrays (254 sample pairs) and Illumina 2.5M Omni arrays (206 sample pairs) was performed for 460 acute myeloid leukemia samples. This Series represents the Affymetrix dataset.

INSTRUMENT(S): [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array

SUBMITTER: Richard Aplenc  

PROVIDER: GSE95496 | GEO | 2017-04-10

SECONDARY ACCESSION(S): PRJNA377277

REPOSITORIES: GEO

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Publications


Childhood acute myeloid leukemia (AML) is frequently characterized by chromosomal instability. Approximately 50% of patients have disease relapse, and novel prognostic markers are needed to improve risk stratification. We performed genome-wide genotyping in 446 pediatric patients with de novo AML enrolled in Children's Oncology Group (COG) studies AAML0531, AAML03P1, and CCG2961. Affymetrix and Illumina Omni 2.5 platforms were used to evaluate copy-number alterations (CNAs) and determine their a  ...[more]

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