Dataset Information


Vitamin D regulates expression of multiple genes including CD14 and CD180 to modulate the syncytiotrophoblast response to lipopolysaccharide

ABSTRACT: We assessed the response of primary cultures of human trophoblasts to bioactive 1,25 (OH)2D3 and used whole genome microarray to identify innovative hypotheses. Data indicate that bioactive vitamin D has wide-spread effects on villous gene expression in general, and a specific affect effect on the immune response. Overall design: Primary human villous cytotrophoblasts were isolated as described {Chen et al., 2010, Am J Physiol Cell Physiol, 299, C968-76; Chen et al., 2015, Placenta, 36, 847-53} and washed thoroughly 4 h after plating, to eliminate villous fragments and nonviable cells.

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Silvija Cvitic  

PROVIDER: GSE95497 | GEO | 2017-09-05



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