Genomics

Dataset Information

36

Regulation of microRNA in myositis skeletal muscle after exercise (microRNA)


ABSTRACT: To identify changes in skeletal muscle microRNA expression after exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis and dermatomyositis Overall design: Total RNA obtained from vastus lateralis before and after 12 weeks of endurance exercise (n = 3) compared to before and after nonexercise, control group (n = 3)

INSTRUMENT(S): [miRNA-3] Affymetrix Multispecies miRNA-3 Array

SUBMITTER: Kanneboyina Nagaraju  

PROVIDER: GSE95735 | GEO | 2017-10-31

SECONDARY ACCESSION(S): PRJNA378236

REPOSITORIES: GEO

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Publications


<h4>Objective</h4>To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients.<h4>Methods</h4>Following a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital:  ...[more]

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