ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing (RNA-seq)

ABSTRACT: We performed a transcriptomic and epigenomic study in patient-derived B-cell lines to investigate the genome-scale effects of DNMT3B dysfunction. We highlighted that altered intragenic CpG-methylation impairs multiple aspects of transcriptional regulation, like alternative TSS usage, antisense transcription and exon splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95743 | GEO | 2017/03/07

SECONDARY ACCESSION(S): PRJNA378324

REPOSITORIES: GEO