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Transcriptional profiling of diabetic peripheral neuropathy patients, diabetic patients, and healthy participants

ABSTRACT: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients, because its pathogenesis remains controversial. In this study, using microarray-based genome-wide expression analyses, we sought to identify both common and distinct mechanisms underlying the pathogenesis of DM and DPN. The results demonstrated that down-regulation of the neurotrophin-MAPK signaling pathway may be the major mechanism of DPN pathogenesis, thus providing a potential approach for DPN treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95849 | GEO | 2017/03/09

SECONDARY ACCESSION(S): PRJNA378558

REPOSITORIES: GEO

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