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Uncovering novel roles for thyroid hormones in teleost fishes: Differential transcriptome regulation in brain and liver by 3,5-T2 and 3’,3,5-T3

ABSTRACT: We used a RNA-seq approach to determine the effect of 3,5-di-iodothyronine (T2) and 3,5,3'-tri-iodothyronine (T3) exogenous treatment on the transcriptome of tilapia (Oreochromis niloticus) liver, cerebellum, and thalamus-pituitary. We identified a total of 169, 154 and 2863 genes that were Thyroid hormone-regulated (FDR < 0.05) in tilapia cerebellum, thalamus-pituitary and liver, respectively. Among those, 130, 96 and 349 genes were uniquely regulated by T3, whereas 22, 40 and 929 were only regulated by T2 in the cerebellum, thalamus-pituitary and liver.

ORGANISM(S): Oreochromis niloticus

PROVIDER: GSE96046 | GEO | 2017/04/10

SECONDARY ACCESSION(S): PRJNA378665

REPOSITORIES: GEO

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