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The RFX transcription factor gene, daf-19, has dual funcitons in ciliated and non-ciliated neurons

ABSTRACT: Cilia are required for many sensory and motility related functions and are involved in growing number of genetic disorders termed ciliopathies. DAF-19, RFX type transcription factor controls expression of many cilia structure and function related genes. To this end, transcriptional profiling of daf-19 mutants (which do not form cilia) and wild-type animals was performed using selectively staged larval stages where cilia mature and maintained, structurally as well as functionally.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE96068 | GEO | 2018/01/31

REPOSITORIES: GEO

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Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.

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