Genomics

Dataset Information

18

Phenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Sentrix BeadChip Array HumanHap300 Genotyping BeadChip 317K, TagSNP Phase I, v1.1

SUBMITTER: Jan P Dumanski   

PROVIDER: GSE9609 | GEO | 2007-12-11

SECONDARY ACCESSION(S): GSE9608GSE9559PRJNA103459

REPOSITORIES: GEO

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Publications


The exploration of copy-number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic makeup between twins derived from the same zygote represent an irrefutable example of somatic mosaicism. We studied 19 pairs of monozygotic twins with either concordant or discordant phenotype by using two platforms for genome-wide CNV analyses and showed that CNVs exist within pairs in both groups. These findings have an impact on our views of gen  ...[more]

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