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Genome-wide profiling of somato-dendritic mRNA distribution in the hippocampus in RNG105/caprin1 conditional knockout (cKO) mice

ABSTRACT: Background: mRNA localization and translation in neuronal dendrites are the basis for long-term synaptic plasticity and memory formation. RNA granules, membrane-less macromolecular assemblies in which dendritic mRNAs are recruited, are thought to contribute to these processes. RNG105/caprin1 is an RNA granule assembly factor involved in mRNA transport. Results: Genome-wide profiling of mRNA distribution in distinct hippocampal layers revealed dendritically and somatically enriched mRNAs, and demonstrated marked reduction in the differential somato-dendritic localization of the mRNAs in RNG105 cKO mice. Conclusion: RNG105 is an essential factor for the localization of many, but particularly for specific mRNAs localized to dendrites.

ORGANISM(S): Mus musculus

PROVIDER: GSE96552 | GEO | 2017/11/24

SECONDARY ACCESSION(S): PRJNA378997

REPOSITORIES: GEO

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