Transcriptomics,Genomics

Dataset Information

45

Global hepatic gene expression data from PPARa liver-specific KO and PPARa liver wild-type male mice fed ad libitum


ABSTRACT: To identify genes whose expression is under the strict dependence of hepatocyte PPARa activity, we used a mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to their liver WT littermates (albumin-Cre-/- Pparaflox/flox or LWT) fed ad libitum or fasted for 24 hours. Overall design: There are 24 liver samples, each from an individual mouse. The samples are from Ppara liver KO (LKO) and liver WT (LWT) male mice of 8 week-old from the same genetic background (C57Bl/6J) fed ad libitum or fasted for 24 hours (n=6 mice/genotype/group). All mice were sacrified at ZT16.

INSTRUMENT(S): Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Feature Number version]

SUBMITTER: Hervé Guillou  

PROVIDER: GSE96559 | GEO | 2017-12-16

SECONDARY ACCESSION(S): PRJNA379007

REPOSITORIES: GEO

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Publications


The liver plays a central role in the regulation of fatty acid metabolism. Hepatocytes are highly sensitive to nutrients and hormones that drive extensive transcriptional responses. Nuclear hormone receptors are key transcription factors involved in this process. Among these factors, PPARα is a critical regulator of hepatic lipid catabolism during fasting. This study aimed to analyse the wide array of hepatic PPARα-dependent transcriptional responses during fasting. We compared gene expression i  ...[more]

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