Transcriptomics

Dataset Information

19

Gene Expression Profiling Reveals Biological Insights into the Pathophysiology of Waldenströms macroglobulinemia


ABSTRACT: Waldenströms macroglobulinemia (WM) is a rare lymphoproliferative disorder with apparent morphologic and immunophenotypic heterogeneity and its origins are still poorly understood. In this study, using Gene-Expression Profiling (GEP), we compared the global mRNA expression patterns of CD19+ WM B cells (WM-BC) and CD138+ WM plasma cells (WM-PC) with those of normal CD19+ peripheral blood B cells (PB-BC), tonsil-BC (T-BC), CD138+ T-PC and bone marrow PC (N-PC). Keywords: Comparison of different immological cells Overall design: The sample cohort studied consisted of CD19-selected peripheral blood B cells (PB-BC; n = 7), tonsil B cells (T-BC; n = 7), bone marrow B cells from WM (WM-BC; n = 12), tonsil plasma cells (T-PC; n = 9), bone marrow plasma cells from healthy donors (N-PC; n = 10), WM plasma cells (WM-PC, n = 9), and MM plasma cells (MM-PC; n = 11).

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Yiming Zhou   

PROVIDER: GSE9656 | GEO |

SECONDARY ACCESSION(S): PRJNA103529

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2011-06-10 | E-GEOD-9656 | ArrayExpress
2016-05-22 | E-GEOD-81443 | ArrayExpress
| GSE56464 | GEO
2015-04-30 | E-GEOD-6691 | ArrayExpress
| GSE12668 | GEO
2014-08-04 | E-GEOD-6691 | ExpressionAtlas
2010-10-18 | GSE21304 | GEO
| EGAS00001001196 | EGA
| EGAS00001001197 | EGA
2012-03-27 | E-GEOD-21304 | ArrayExpress