Expression data from Hdac1 and 2 knock out microglia in 5X familial Alzheimer's disease (FAD) background

ABSTRACT: Epigenetic alterations has been implicated in the pathology of several neurodegenerative diseases. To investigate the role of microglial Hdac1 and 2 in the pathogenesis of Alzheimer's disease (AD), we created microglia specific compound Hdac1 and Hdac2 knock out mice in 5X FAD background. Genetic ablation of Hdac1 and 2 from microglia reduced amyloid plaque burden and improved spatial learning and memory function. To study how Hdac1 and 2 knock out in microglia alters gene expression profile in 5X FAD mice we carry out microarray analysis using 24-28 weeks animals

ORGANISM(S): Mus musculus

PROVIDER: GSE96622 | GEO | 2018/03/14

REPOSITORIES: GEO