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ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PXD006074PRJNA379623PRJNA379617PRJNA379618

ORGANISM(S): Homo sapiens

PROVIDER: GSE96778 | GEO | 2017/05/11

SECONDARY ACCESSION(S): PRJNA379618

REPOSITORIES: GEO

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ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.

Project description: Not available

| S-EPMC5452029 | biostudies-literature

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator

Project description:Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex and HOT1, while subtelomeric variant repeats are recognized by NR2C/F transcription factors. Recently, the Kruppel-like zinc finger protein ZBTB48 has been described as a novel telomere-associated factor in the vertebrate lineage. Here, we show that ZBTB48 binds directly both to telomeric as well as to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric function, we demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism.

2017-05-11 | PXD006074 | Pride

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator [RNA-seq]

Project description:Here we show that ZBTB48 binds directly both to telomeric as well as to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric function, we demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism.

2017-05-11 | GSE96777 | GEO

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator [ChIP-seq]

2017-05-11 | GSE96776 | GEO

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator

Project description:ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator

| PRJNA379618 | ENA

On the relationship of protein and mRNA dynamics in vertebrate embryonic development

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Distinct clades of TELOMERE REPEAT BINDING transcriptional regulators interplay to regulate plant development.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-12 | GSE253016 | GEO

GalR Acts as a Transcriptional Activator of galKT in the Presence of Galactose in Streptococcus pneumoniae

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2015-10-30 | E-GEOD-74502 | biostudies-arrayexpress

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TALE transcription factors binding and transcriptional effect

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