Osteogenic programming of adipose-derived mesenchymal stem cells using a fungal metabolite that suppresses the Polycomb protein EZH2

ABSTRACT: We report genome-wide expression changes that occur in adipose-derived mesenchymal stem cells upon treatment with CytoD cytoskeletal drug. mRNA-Seq analysis shows that CytoD-treated samples cluster together. In addition, we also see that cells treated with CytoD show upregulation of osteogenic markers, epiregulators, and a number of key molecular function pathways including extracellular matrix, cell membrane gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE96788 | GEO | 2017/03/21

SECONDARY ACCESSION(S): PRJNA379707

REPOSITORIES: GEO