Genomics

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A structural “toggle” in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency


ABSTRACT: Purpose: To assess the global impacts of RNaseH domain alleles of Prp8 on the in vivo splice site selection for native introns. Conclusions: Our study reveals functional links between distinct spliceosomal conformations and splicing fidelity.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE96891 | GEO | 2017/06/21

SECONDARY ACCESSION(S): PRJNA380015

REPOSITORIES: GEO

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