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Different expression profiles of lncRNAs, mRNAs and circRNAs in preeclampsia and normal placenta None

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE96985 | GEO | 2018/03/01

REPOSITORIES: GEO

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Different expression profiles of lncRNAs, mRNAs and circRNAs in preeclampsia and normal placenta (ceRNA)

Project description:Preeclampsia is usually considered as a placental basis of diseases, as there are many differently expressed proteins or pathogenic proteins expressed in the placenta. Owing to the important role of post-transcriptional gene regulation in phenotypes and functions of cells, non-coding ribonucleic acid (ncRNA) molecules contributed to the regulation. We collected 7 placental samples from 3 preeclampsia patients and 4 normal women, focused on the basal plate of placenta, as it is the direct connection of mother and fetal, and adopted SBC human ceRNA array V1.0（4×180K）and human miRNA microarray (8*60 K). The results revealed that expressions of 2840 lncRNAs, 1093 mRNAs, 4282 circRNAs and 4 miRNAs were different between preeclampsia and normal placentas. The functions of differentially expressed lncRNAs and co-expressed potential targeting genes were predicted by analyzing Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analysis. Furthermore, we analyzed and find the co-expression and interaction patterns of different RNAs and possible ceRNA mechanism. The present study provided a systematic perspective on the potential function of non-coding RNAs (ncRNAs) in the pathogenesis of preeclampsia.

2018-03-01 | GSE96984 | GEO

Different expression profiles of lncRNAs, mRNAs and circRNAs in preeclampsia and normal placenta None

Project description:Different expression profiles of lncRNAs, mRNAs and circRNAs in preeclampsia and normal placenta None

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Different expression profiles of mRNAs in preeclampsia and normal placenta (mRNA)

Project description:Preeclampsia (PE), which results from abnormal placentation, acts as a primary cause of maternal and neonatal morbidity and mortality. However, the cause of abnormal development of placenta remain poorly understood.Recently, it has been proposed that the genes that are differnetially expressed between PE and normal placenta tissues are associated with PE pathogenesis. To further elucidate the pathogenesis, we conducted transcriptional profiling of mRNA between PE and normal placenta tissues.

2023-04-23 | GSE149812 | GEO