Genomics

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Transcriptional profiling of kidneys from ADTKD-UMOD mouse model


ABSTRACT: To gain insight into autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin (UMOD) pathophysiology, we carried out transcriptional profiling of kidneys from 1- and 2-month-old TgUmodC147W mice, a transgenic model that recapitulates the main features of the disease, and TgUmodwt mice, a matched transgenic control of Umod overexpression. These time points correspond to presymptomatic stages that precede renal dysfunction in TgUmodC147W mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE97093 | GEO | 2017/08/18

SECONDARY ACCESSION(S): PRJNA380658

REPOSITORIES: GEO

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