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Genome-wide maps of histone modification in mast cells

ABSTRACT: Epigenomic studies demonstrate that monomethylation of lysine residue 4 on histone 3 (H3K4me1) marks genes that are poised to be transcribed, whereas acetylation of lysine residue 27 on histone 3 (H3K27ac) identifies genes that are actively being transcribed. The combined presence of H3K4me1 and H3K27ac modifications predicts enhancer activity. To detect these marks genome-wide, we performed H3K4me1 and H3K27ac ChIP-seq analysis of mast cells to identify the putative mast cell enhancers.

ORGANISM(S): Mus musculus

PROVIDER: GSE97253 | GEO | 2018/03/01

REPOSITORIES: GEO

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