Dataset Information


Expression data from wild type mice and REDD1 null mice following acute aerobic exercise

ABSTRACT: Regulated in DNA Damage and Development 1 (REDD1) is a stress induced protein whose expression is highly induced in skeletal muscle following a single bout of aerobic exercise. However, the role of this induction is unknown We used microarrays to detail the change in gene signature within skeletal muscle following a single bout of aerobic exercise in wild type and REDD1 null mice Overall design: Wild type and REDD1 knockout mice were randomized to remain sedentary or undergo a single bout of aerobic exercise. One hour following the completion of the exercise protocol, the plantaris from sedentary and exercised mice was extracted and frozen.

INSTRUMENT(S): [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]

SUBMITTER: Alexey M Eroshkin  

PROVIDER: GSE97415 | GEO | 2017-10-05



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REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.

Gordon Bradley S BS   Steiner Jennifer L JL   Rossetti Michael L ML   Qiao Shuxi S   Ellisen Leif W LW   Govindarajan Subramaniam S SS   Eroshkin Alexey M AM   Williamson David L DL   Coen Paul M PM  

American journal of physiology. Endocrinology and metabolism 20170912 6

The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through changes in gene expression. However, the transducers that mediate altered gene expression signatures have not been completely elucidated. Regulated in development and DNA damage 1 (REDD1) is a stress-induced protein whose expression is transiently increased in skeletal muscle following acute aerobic exercise. However, the role of this induction remains unclear. Because  ...[more]

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