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A Unique B-cell Regulome links Notch to Downstream Oncogenic Pathways in Small B-cell Lymphoma

ABSTRACT: We perform integrative analysis of Notch-dependent transcripts, genome-wide binding of Notch transcription complex subunits, and enhancer-promoter interactions to identify direct Notch target genes, including the oncogene MYC, and validate their relevance to mantle cell lymphoma and chronic lymphocytic leukemia in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE97541 | GEO | 2018/06/03

REPOSITORIES: GEO

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A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

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