Genomics

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H3K27me3 localization during B cell differentiation


ABSTRACT: B cells are poised to differentiate into antibody secreting plasma cells however the remodeling of repressive epigenetic modifciations are not well understood during this cell fate transition. Therefore, ChIP-seq was performed for H3K27me3 in naive splenic B cells and LPS induced splenic antibody secreting plasmablasts. These data define a role for Ezh2 dependent H3K27me3 in the regulation of murine B cell differentiation in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE97695 | GEO | 2017/12/16

SECONDARY ACCESSION(S): PRJNA382686

REPOSITORIES: GEO

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