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Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE97926 | GEO | 2018/01/17

SECONDARY ACCESSION(S): PRJNA383354

REPOSITORIES: GEO

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Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells [RNA-Seq]

Project description:Here we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undectable in serum soon after mice were shifted back to chow diet (CD). In contrast, myeloid cell responses towards innate stimuli remained broadly augmented. WD induced transcriptomic and epigenomic reprogramming of myeloid progenitor cells, leading to increased proliferation as well as enhanced innate immune and interferon responses towards in vivo LPS challenge. QTL analysis in human monocytes trained with oxidized low-density lipoprotein (oxLDL) and stimulated with LPS suggested inflammasome-mediated trained immunity. Consistently, Nlrp3-/-/Ldlr-/--deficient mice lacked WD-induced systemic inflammation or myeloid progenitor proliferation and reprogramming. Hence, NLRP3 mediates trained immunity following WD and could thereby arbitrate the potentially deleterious effects of trained immunity in inflammatory diseases.

2018-01-17 | GSE97925 | GEO

Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells [ATAC-Seq]

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Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

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Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells

Project description:Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells

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Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells II [RNA-Seq]

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Microbial reprogramming inhibits Western diet-associated obesity.

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Persistent Epigenetic Reprogramming of Sweet Taste by Diet

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-11 | GSE146245 | GEO

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Polypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction

Project description:Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, subdermal mesh implantation induces a rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloid cells segregate into distinct macrophage subsets with separate spatial distribution, activation profiles and functional properties. Protein mass spectrometry confirms the inflammatory nature of the foreign body reaction, as characterized by cytokines, complement activation and immunoglobulin deposition.

2019-01-24 | PXD009944 | Pride

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