Genomics

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Hormone-dependent control of developmental timing through regulation of chromatin accessibility


ABSTRACT: We identify a temporal cascade of ecdysone-inducible transcription factor gene expression during Drosophila wing development. This temporal cascade corresponds with dynamic changes in chromatin accesibility during wing development. We hypothesized that these temporally regulated transcription factors may coordinate these dynamic open chromatin changes. To test this, we investigate the ecdysone-inducible transcription factor, E93, which we determine is required for coordinating transitions in developmental stage by regulating chromatin accesibility of cis-regulatory elements.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE97956 | GEO | 2017/06/06

SECONDARY ACCESSION(S): PRJNA383482

REPOSITORIES: GEO

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