Genomics

Dataset Information

157

GABPA ChIP-seq in human monocytic THP-1 cells


ABSTRACT: ChIP-seq for GABPA in THP-1 cells after stimulation with the the natural VDR ligand 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) Overall design: THP-1 cells were treated for 24 h with 100 nM 1,25(OH)2D3 or vehicle before ChIP assay

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Carsten Carlberg  

PROVIDER: GSE98093 | GEO | 2017-09-28

SECONDARY ACCESSION(S): PRJNA383990

REPOSITORIES: GEO

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Publications

ETS transcription factor family member GABPA contributes to vitamin D receptor target gene regulation.

Seuter Sabine S   Neme Antonio A   Carlberg Carsten C  

The Journal of steroid biochemistry and molecular biology 20170911


Binding motifs of the ETS-domain transcription factor GABPA are found with high significance below the summits of the vitamin D receptor (VDR) cistrome. VDR is the nuclear receptor for the biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). In this study, we determined the GABPA cistrome in THP-1 human monocytes and found that it is comprised of 3822 genomic loci, some 20% of which were modulated by 1,25(OH)2D3. The GABPA cistrome showed a high overlap rate wit  ...[more]

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