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Determination of Lsd1 function in C2C12 myoblast cells by global transcriptome analysis

ABSTRACT: First, we aimed to identify genes whose transcript levels change at the onset of myogenic versus adipogenic differentiation of muscle precursors. We therefore compared RNA-seq results obtained from C2C12 cells differentiated for 1 day in myogenic and adipogenic medium. Out of these genes, we wanted to determine those whose expression was affected by altered Lsd1 levels. To this end, we performed RNA-seq in C2C12 cells upon LSD1 overexpression and Lsd1 knock-down in adipogenic medium and compared them to corresponding control cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE98133 | GEO | 2017/12/15

SECONDARY ACCESSION(S): PRJNA384057

REPOSITORIES: GEO

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