Dataset Information


Transcriptome sequencing analyses of WT and DDX46+/- macrophages

ABSTRACT: DDX46 is identified to be required at the early step of pre-spliceosome assembly,but whether DDX46 could regulate antiviral transcripts isoform splicing in the nucleus remain elusive. Overall design: Transcriptome sequencing analyses of WT and DDX46+/- macrophages from mouse peritoneal macrophages infected with VSV for 8 h.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: ql zheng  

PROVIDER: GSE98359 | GEO | 2017-08-28



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The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus.

Zheng Qingliang Q   Hou Jin J   Zhou Ye Y   Li Zhenyang Z   Cao Xuetao X  

Nature immunology 20170828 10

DEAD-box (DDX) helicases are vital for the recognition of RNA and metabolism and are critical for the initiation of antiviral innate immunity. Modification of RNA is involved in many biological processes; however, its role in antiviral innate immunity has remained unclear. Here we found that nuclear DDX member DDX46 inhibited the production of type I interferons after viral infection. DDX46 bound Mavs, Traf3 and Traf6 transcripts (which encode signaling molecules involved in antiviral responses)  ...[more]

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