Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor

ABSTRACT: Even the latest generation of base editor (BE3) causes unwanted indels and non-C-to-T substitutions, compromising the fidelity of base editing outcome. Here we report a enhanced base editing system. The enhanced base edting system decreased the formation of unintended indels and C-to-A/C-to-G substitutions, and increased the frequency of desired C-to-T substitution, thereby improving both the accuracy and efficiency of base editing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE98685 | GEO | 2017/08/29

SECONDARY ACCESSION(S): PRJNA385910

REPOSITORIES: GEO