Muscle directs diurnal energy homeostasis through a myokine-dependent hormone module in Drosophila

ABSTRACT: Inter-tissue communication is critical to control organismal energy homeostasis in response to temporal changes in feeding and activity or external challenges. Muscle is emerging as a key mediator of this homeostatic control through consumption of lipids, carbohydrates, and amino acids, as well as governing systemic signaling networks. However, it remains less clear how energy substrate usage tissues, such as muscle, communicate with energy substrate storage tissues in order to adapt with diurnal changes in energy supply and demand. Using Drosophila, we show here that muscle plays a crucial physiological role in promoting systemic synthesis and accumulation of lipids in fat storage tissues through Foxo. To gain more insight into these tissue-specific changes in lipid metabolism, we generated genome-wide expression profiles from dissected thoraces (enriched in indirect flight muscle), carcass (enriched in fat body), and intestines of Act88FG4>FoxoRNAi flies and control animals.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE98789 | GEO | 2017/07/03

SECONDARY ACCESSION(S): PRJNA386203

REPOSITORIES: GEO