Dataset Information


Effect of Analytic Treatment Interruption of Antiretroviral Therapy on HIV Reservoirs and Immunological Parameters

ABSTRACT: We compared transcriptional profiles of CD4+ and CD8+ T lymphocytes from HIV infected individuals before and 1 year after interruption of antiretroviral therapy (ART). Overall design: CD4+ and CD8+ T lymphocytes isolated from periphral blood of 7 study participants before (pre-ATI) and 1 year after (post-ATI) analytic antiretroviral therapy interruption (ATI).

INSTRUMENT(S): [HG-U219] Affymetrix Human Genome U219 Array

ORGANISM(S): Homo Sapiens

SUBMITTER: Jana Blazkova  

PROVIDER: GSE98902 | GEO | 2018-01-01



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Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals.

Clarridge Katherine E KE   Blazkova Jana J   Einkauf Kevin K   Petrone Mary M   Refsland Eric W EW   Justement J Shawn JS   Shi Victoria V   Huiting Erin D ED   Seamon Catherine A CA   Lee Guinevere Q GQ   Yu Xu G XG   Moir Susan S   Sneller Michael C MC   Lichterfeld Mathias M   Chun Tae-Wook TW  

PLoS pathogens 20180111 1

Therapeutic strategies aimed at achieving antiretroviral therapy (ART)-free HIV remission in infected individuals are under active investigation. Considering the vast majority of HIV-infected individuals experience plasma viral rebound upon cessation of therapy, clinical trials evaluating the efficacy of curative strategies would likely require inclusion of ART interruption. However, it is unclear what impact short-term analytical treatment interruption (ATI) and subsequent reinitiation of ART h  ...[more]

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