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Expression data from 2 wildtype and 8 C. elegans ETC mutants

ABSTRACT: Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. Keywords: Wildtype vs mutant comparison as a method for studying contributors to disease processes

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE9897 | GEO | 2008/02/14

SECONDARY ACCESSION(S): PRJNA105145

REPOSITORIES: GEO

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Transcription profiling from C. elegans ETC mutants vs. Wildtypes

Project description:Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele; Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. Experiment Overall Design: 3 biological replicates of each C. elegans strain were used as sources of total RNA combined for hybridization to a single Affymetrix whole-genome microarray. Comparison of the data was intended to reveal metabolic pathways downstream of the mutation.

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Expression data from wildtype and gas-1 mitochondrial mutant C. elegans

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