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Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

ABSTRACT: Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg stimulated macrophages. Methods: Bone marrow derived macrophage mRNA profiles of 7 weeks of wild type (WT) and Sema6D-/- mice were stimulated by LPS for 4 hrs. Results: According to this comparison, we found that 550 genes were downregulated in Sema6D-/- macrophages than WT macrophages in response to LPS. Conclusions: Our study represents 62 genes were supressed in both M1 and M2 Sema6D-/- macrophage than WT macrophages, suggesting of Sema6D reverse sigaling genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE99047 | GEO | 2018/05/20

REPOSITORIES: GEO

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