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Cardiac Gene Expression Profiling in CryAB R120G Transgenic Mice

ABSTRACT: Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small HSP ?B-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of glucose 6-phosphate dehydrogenase (G6PD) and 'reductive stress' (Rajasekeran et al., Cell. 2007;130(3):401-2). However, the initiating molecular events in the pathogenesis of this novel toxic gain-of-function mechanism remain poorly defined. In an integrated systems approach using gene expression profiling, we identified a 'biosignature,' whose features can be validated to predict the onset, rate of progression, and clinical outcome of R120GCryAB cardiomyopathy. Keywords: time-course, genetic modification, disease state analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE9924 | GEO | 2008/12/12

SECONDARY ACCESSION(S): PRJNA103925

REPOSITORIES: GEO

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Cardiac Gene Expression Profiling in CryAB R120G Transgenic Mice

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