Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferation

ABSTRACT: We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.  Geriatric fractures take longer to heal and heal with more complications than those of younger patients; however, the mechanistic basis for this difference in healing is not well understood. To improve this understanding, we investigated cell and molecular differences in fracture healing between 5 month-old (young adult) and 25 month-old (geriatric) mice healing utilizing high-throughput analysis of gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE99388 | GEO | 2018/01/01

SECONDARY ACCESSION(S): PRJNA388355

REPOSITORIES: GEO