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Genomic profiles of oxidative stress-induced renal cell carcinomas developed in Mutyh deficient mice

ABSTRACT: Intraperitoneal administration of ferric nitrilotriacetate initiates Fenton reaction in the renal proximal tubules in rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of oxidative stress-induced RCCs and simultaneously developed malignant lymphomas in the mice. The results highlighted a substantial difference in the predisposition to chromosomal changes between animal species.

ORGANISM(S): Mus musculus

PROVIDER: GSE99535 | GEO | 2017/10/06

SECONDARY ACCESSION(S): PRJNA388755

REPOSITORIES: GEO

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