Dataset Information


Metabolic products of an obesity-associated microbiome impact host metabolism and disease risk by altering the epigenome

ABSTRACT: We profiled the gut microbiome and chromatin features at DNA cis-regulatory elements in colon epithelium from mice fed either an obesogenic or control diet. Overall design: Examination of 2 different histone modifications and gene expression in mice colon epithelium, microbiome in male fecal samples

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Paul A Wade  

PROVIDER: GSE99670 | GEO | 2017-12-19



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An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression.

Qin Yufeng Y   Roberts John D JD   Grimm Sara A SA   Lih Fred B FB   Deterding Leesa J LJ   Li Ruifang R   Chrysovergis Kaliopi K   Wade Paul A PA  

Genome biology 20180123 1

BACKGROUND:The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How the host mediates epigenomic responses to gut microbiota is an emerging area of interest. Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obeso  ...[more]

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