Genomics

Dataset Information

0

CYP3A5 Gene Expression is Associated with Early Recurrence of Non-small Cell Lung Cancer


ABSTRACT: Study to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Purpose: Recent clinical trials suggest improvement in survival with adjuvant chemotherapy in non-small cell lung cancer (NSCLC). This study's aim is to identify genes associated with NSCLC recurrence in patients not receiving adjuvant chemotherapy. Experimental design: Banked NSCLC tumors of patients who underwent resection of stage Ia-IIIb disease were identified. Patients were stratified into two groups: recurrent (R, n=11) or non-recurrent (NR, n=16) 2 years after surgery. Microarray profiling and Cox multivariate analysis were performed. Conclusion: Increased CYP3A5 gene expression correlates with NSCLC recurrence and promotes proliferation through mechanisms that may involve, in part, CYP3A5 epoxygenase activity. Keywords: comparison of gene expression profiles for recurrent and non-recurrent cancer

ORGANISM(S): Homo sapiens

PROVIDER: GSE9971 | GEO | 2009/12/01

SECONDARY ACCESSION(S): PRJNA103989

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-9971 | biostudies-arrayexpress
| E-MTAB-13555 | biostudies-arrayexpress
| E-GEOD-25019 | biostudies-arrayexpress
2023-08-24 | GSE222073 | GEO
2017-12-25 | GSE108492 | GEO
2022-11-16 | GSE217978 | GEO
2020-10-21 | PXD021682 | Pride
2020-10-21 | PXD021275 | Pride
| E-GEOD-3593 | biostudies-arrayexpress
2015-10-20 | MSV000079352 | MassIVE