Transcriptomics,Genomics

Dataset Information

20

Genes differentially regulated by miR-489


ABSTRACT: To investigate genes regulated by miR-489, gene expression analysis was carried out between control siRNA and miR-489 mimic transfected cells. Overall design: T47D cells were transfected with miR-489 mimic or control scramble siRNA for 72 hours. RNA was isolated 72 hours post transfection using trizol reagent. Eacsh sample was collected in triplicate.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Hexin Chen  

PROVIDER: GSE99728 | GEO | 2018-04-30

REPOSITORIES: GEO

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Publications

Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer.

Soni Mithil M   Patel Yogin Y   Markoutsa Eleni E   Jie Chunfa C   Liu Shou S   Xu Peisheng P   Chen Hexin H  

Molecular cancer research : MCR 20180521 9


It is postulated that the complexity and heterogeneity in cancer may hinder most efforts that target a single pathway. Thus, discovery of novel therapeutic agents targeting multiple pathways, such as miRNAs, holds promise for future cancer therapy. One such miRNA, miR-489, is downregulated in a majority of breast cancer cells and several drug-resistant breast cancer cell lines, but its role and underlying mechanism for tumor suppression and drug resistance needs further investigation. The curren  ...[more]

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