MYD88 L265P differential expression analysis

ABSTRACT: The wider transcriptional effects of MYD88L265P were explored by analysing the microarray datasets using the limma package. We focussed on evidence for differential expression between Myd88L265P and Card11L232LI transduced B cells because both cell populations were actively proliferating at the time of RNA isolation. When the transcriptome of MYD88L265P expressing B cells was compared with empty vector-expressing B cells using limma, 111 genes had strong evidence for differential expression with 88 increased in MYD88L265P cells. Compared to CARD11L232LI expressing B cells, 84 genes had strong evidence for differential expression in MYD88L265P B cells with 30 increased, including the plasma cell induced genes Prdm1 and Igj.

ORGANISM(S): Mus musculus

PROVIDER: GSE99775 | GEO | 2017/06/08

SECONDARY ACCESSION(S): PRJNA389579

REPOSITORIES: GEO