Transcriptomics,Genomics

Dataset Information

35

Expression data of adult quiescent and activated mouse neural stem cells


ABSTRACT: Neural stem cells were sorted according to their activated or quiescent state by flow cytometry using a set of 3 markers (LeX, CD24 and EGFR) We used microarrays to detail the global programme of gene expression underlying the proliferation/quiescence balance. Overall design: Neural stem cells were freshly sorted from adult mouse subventricular zone by flow cytometry and Affymetrix GeneChip MOE 430 2.0 microarrays were hybridized.

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

SUBMITTER: Marc-André MOUTHON  

PROVIDER: GSE99777 | GEO | 2018-01-01

SECONDARY ACCESSION(S): PRJNA389587

REPOSITORIES: GEO

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Publications

Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment.

Morizur Lise L   Chicheportiche Alexandra A   Gauthier Laurent R LR   Daynac Mathieu M   Boussin François D FD   Mouthon Marc-André MA  

Stem cell reports 20180705 2


Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs) is crucial for the development of therapeutic strategies based on the stimulation of their endogenous regenerative potential in the damaged brain. We show that LeXbright cells sorted from the adult mouse subventricular zone exhibit all the characteristic features of quiescent NSCs. Indeed, they constitute a subpopulation of slowly dividing cells that is able to enter the cell cycle to regenerate the irradia  ...[more]

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