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Meg3 binding sites in mouse insulinoma cells

ABSTRACT: We have shown that increased β-cell proliferation in functioning pancreatic neuroendocrine tumors (insulinomas) correlated with reduced expression of the long non-coding RNA Meg3 and increased expression of the oncogenic receptor c-Met. To investigate the target binding sites of Meg3 in and around the c-Met gene, we did ChIRP-Seq using biotinylated probes from the mouse Meg3 RNA sequence. This would help us better understand how Meg3 regulates ithe expression of c-Met to control β-cell proliferation in insulinoma cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE99798 | GEO | 2017/09/20

SECONDARY ACCESSION(S): PRJNA389664

REPOSITORIES: GEO

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